SCREENING OF A FOCUSED UBIQUITIN-PROTEASOME PATHWAY INHIBITOR LIBRARY IDENTIFIES SMALL MOLECULES AS NOVEL MODULATORS OF BOTULINUM NEUROTOXIN TYPE A TOXICITY

Botulinum neurotoxins (BoNTs) are known as the most potent bacterial toxins, which can cause potentially deadly disease botulism.BoNT Serotype A (BoNT/A) is the most studied serotype as it is responsible for most human botulism cases, and its formulations are extensively utilized in clinics for therapeutic and cosmetic applications.BoNT/A has the l

This work fits into the broader academic debate on the legitimacy of the Sociology of Cultural Heritage.The origin of the term itself is investigated by analyzing COMBAT WHITE CHOCO RASPBERRY the words that compose it and their interpretation in the context of post-modern society.The paper then explores some specific aspects of the discipline, such

Hydrocephalus is a known complication following surgical resection of a cerebral hemisphere for refractory epilepsy, Hotplate Control Switch yet the pathological mechanism remains poorly understood.We present a case of refractory aseptic inflammatory hydrocephalus following cerebral hemispherectomy surgery for refractory epilepsy treated with a com

Oppositional defiant disorder (ODD), one of the psychiatric disorders frequently encountered in childhood, is a disruptive behaviour disorder involving emotional and behavioural problems.Children with ODD may experience difficulty in controlling anger and are generally disobedient and defiant of other people.Risperidone, an atypical antipsychotic a